GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs71636213 | 1 | rs71636213 | chr5:79581768 | CKMT2 | chr5:80529139-80562216:+ | -0.41 | -4.15 | 4.16E-5 | Alzheimer's disease in APOE e4- carriers |
| BLCA | cis | rs78153629 | 1 | rs7164132 | chr15:40675155 | C15orf23 | chr15:40674922-40686488:+ | 0.32 | 5.58 | 4.67E-8 | Heschl's gyrus morphology |
| BLCA | cis | rs78153629 | 1 | rs7166991 | chr15:40671957 | C15orf23 | chr15:40674922-40686488:+ | 0.3 | 5.29 | 2.04E-7 | Heschl's gyrus morphology |
| BLCA | cis | rs78153629 | 1 | rs7169404 | chr15:40675443 | C15orf23 | chr15:40674922-40686488:+ | 0.33 | 5.69 | 2.51E-8 | Heschl's gyrus morphology |
| BLCA | cis | rs2120019 | 1 | rs7173833 | chr15:75369618 | SCAMP5 | chr15:75287901-75313836:+ | 0.26 | 4.46 | 1.07E-5 | Blood trace element (Zn levels) |
| BLCA | cis | rs2120019 | 1 | rs7175720 | chr15:75348962 | SCAMP5 | chr15:75287901-75313836:+ | -0.29 | -4.8 | 2.29E-6 | Blood trace element (Zn levels) |
| BLCA | cis | rs2888674 | 1 | rs717658 | chr7:150503637 | TMEM176A | chr7:150497854-150502208:+ | 0.16 | 4.23 | 2.94E-5 | Forced expiratory volume in 1 second (environmental interaction) |
| BLCA | cis | rs7112513 | 1 | rs718847 | chr11:116734146 | PCSK7 | chr11:117075789-117102811:- | -0.44 | -5.68 | 2.73E-8 | Protein quantitative trait loci |
| BLCA | cis | rs763014 | 1 | rs7205409 | chr16:642610 | WFIKKN1 | chr16:679239-684116:+ | 0.27 | 4.94 | 1.16E-6 | Height |
| BLCA | cis | rs9894429 | 1 | rs7209180 | chr17:79581519 | TSPAN10 | chr17:79609349-79615778:+ | 0.49 | 8.84 | 3.52E-17 | Eye color traits |
| BLCA | cis | rs8072100 | 1 | rs7210738 | chr17:45757598 | C17orf57 | chr17:45401142-45518675:+ | -0.26 | -5.74 | 1.96E-8 | Very long-chain saturated fatty acid levels (fatty acid 20:0) |
| BLCA | cis | rs9902453 | 1 | rs7212497 | chr17:28335949 | EFCAB5 | chr17:28256874-28435469:+ | -0.23 | -3.94 | 9.84E-5 | Coffee consumption (cups per day) |
| BLCA | cis | rs9894429 | 1 | rs7213129 | chr17:79581573 | TSPAN10 | chr17:79609349-79615778:+ | 0.49 | 8.84 | 3.52E-17 | Eye color traits |
| BLCA | cis | rs8078723 | 1 | rs7214085 | chr17:38169095 | ZPBP2 | chr17:38024455-38034144:+ | -0.21 | -3.95 | 9.21E-5 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| BLCA | cis | rs882367 | 1 | rs7214743 | chr17:59498052 | C17orf82 | chr17:59489112-59490641:+ | 0.2 | 4.3 | 2.15E-5 | Sitting height ratio |